Thursday, December 24, 2020

 Of twenty-twenty, we have had a plenty...good bye and good riddance!

Like you, my year started pretty normal. Right out the gate I was off to Edinburgh, Rotterdam, Leiden, Amsterdam and Gdansk, where there is a lovely Ferris wheel (links to photos on my instagram page), all in a two week period. Standard stuff, but by March life had slowed considerably. Ugh@#$%^&* The SARS virus we had been hearing about from China was in Maryland and in all the places I had just visited in the EU. Fortunately, Governor Hogan took steps early to implement quarantine actions. Stay at home orders went into place in March and the University of Maryland complied. Don't go to work if you don't have to we were told. Mask up inside. Limit contact outside your bubble. Social distance. Only "ZOOM" video meetings. Lots of new words in the daily lexicon. For me being use to working from home or where ever I wanted, this didn't sound bad at first. And, by then my lab had dwindle to a few and I was contemplating moving. So, there wasn't much going on in the lab that needed my attention. However, suddenly being forced to work from home felt confining in the same way that pre-COVID working from home had been a luxury. 

Speaking of moving, we did so during the damn pandemic making it our 5th time to move across the continent. Shipped the Kia Sportage to Seattle and rented a lux SUV that Donna drove the entire way every day for five days from BWI to SEA. I worked off and on the whole way and tried be generally as annoying as I felt safe being all in order to help keep her awake. Once there we took a couple days to regroup, picked up the Kia and then moved on Northward. Even got in a lovely lunch with my former driver while we waited on the Kia to arrive at his house near Seatac. Arriving in Victoria on 1 OCT we went straight into quarantine for two weeks - as per government requirements and yes they called to check that we were in fact staying home. No going out. No going off property. Thanks to Donna's foresight in packing all the household things we would need in the two week quarantine when we could not get to our belongings, we were mostly set. And, thanks to delivery of fast-food and groceries it went by well enough bolstered by help from Dave Schibli and Derek Smith. These guys work at the lab I inherited from Christoph Borchers who resigned as Director back in July 2019. They insisted on helping move all of our belongings from their de facto quarantine at the ABF terminal in Surrey (an inexpensive way to move but requires you load your own trailer) which is right at the border. Not a simple journey from Surrey to Victoria as it is three hours one way including a 1.5 hour ferry ride, but these guys insisted on helping even though it meant unloading off the ABF trailer in Surrey onto a UHAUL and then off the UHAUL into our Victoria rental. Long day, but felt like we had arrived to find family waiting on us. 

Just like the 18 years in Seattle, we put down roots in Baltimore in our seven years there making leaving bittersweet. Lots of friends left behind and sadly one homeless man, Leslie Dale Watson, who I had come to know well during my walks to and from work. Too many people to name, but thanks to social media they are virtually close except Dale who I'll likely never have the luxury of chatting with again. And then there was our hundred + year old row house with all of its charm like the marble fireplace that we bid farewell. Sold surprisingly quickly, but then Donna had staged it like a pro! Lots of charm in the historic Bolton Hill neighborhood like the veg and fruit man's horse drawn wagon that we will miss. All of the places we could walk to were also hard to give up as was our lovely patio decorated by Donna enjoyed by Trixie and where I worked and ate many meals. Even our 33rd anniversary was spent in quarantine but in style in the kitchen. Thanks COVID! 

Our oldest, aka Mint, stayed behind in Maryland near the College Park campus where he is finishing up his degree in kinesiology. What he'll do with this degree remains a mystery but he has begun making job applications. Can't imagine the job market will recover by the time he finishes in May 2021, but loads of new graduates will be in this unnerving position. Sadly, this will be the first Christmas we have spent without him. Don't want to dwell on that but hope he can - pandemic pending - find a way to celebrate if even alone. He said perhaps he would be with his Seattle childhood mate Elliott who is now in the Coast Guard and nearby in Virginia. Our youngest on the other hand, aka Ham, is here with us. Soon he'll start his fourth year convalescing from an unknown medical problem causing debilitating muscle soreness. In July he and I traveled to LA to visit Cedars Sinai's Center for Undiagnosed Patients (CUP) to try to shed some light on his condition. CUP uses a team of doctors who meet patients individually and then meet as a group afterward to discuss possible diagnoses. Sadly, none was forthcoming. Even the genetic mutations ordered by the CUP neurologist failed to find anything pathological, sigh. As of now we are set to undergo whole genome sequencing to see if something inheritable shows up. With COVID ravishing LA even more so than when we visited, when even the homeless on the streets had masks on, it could be Summer 2021 before we are able to discuss results with the genetic counselor. 

Our first morning in Victoria we awoke to the strangest feeling brought on by complete and utter silence. Not even any road noise in our Gordon Head neighborhood. Weird because in Baltimore we had become use to the daily sounds of urban life: gunshots, sirens, police helicopters overhead with spot lights at night, traffic scofflaws, pedestrians yelling obscenities at each other, squeegee boys, twelve O'clock boys and all manner of chaos one can imagine in a city where police abdicated control of traffic laws after the Freddy Gray riots. Despite all that, we will always miss Baltimore. What a wonderful and whacky place to live. The urban life - sans traffic scofflaws - suited us. I loved walking where ever I wanted and interacting with all the "scary" people we were warned about when moving there in 2013: "Don't live in the city! It's too dangerous" we were told. Well, it was fine and fun. Fantastic even. In addition to Donna's now good friends she left behind, I met a luthier - Phil Jacoby - who got all my guitars working again after spending decades mostly in their cases. More of this to come on that front I hope.

That's about all I got. We are happy to be at a University that wants me, but sad to have left our friends behind in Baltimore. Indeed, very sad to have left Charm-City with its gritty, funky, friendly folk where grocery store security guards wear bullet proof vests and carry firearms and remind you to "stay safe" as you exit the store. Victoria is quite a bit more boring by comparison, but we'll get use to it - I hope. Happy Holidays from Dave, Donna, Ham and Trixie! We miss you Mint!!!!! Hoping the border opens by the time you graduate so we can be together. Lots of love, hugs and kisses from all of us to all of you.






Wednesday, December 25, 2019

NATIVITATIS MMXIX

As the year winds down I am definitely ready for a break. Seems like I had more travel than usual this year, but it was probably just more international travel. Here https://www.instagram.com/p/BydZuABAfRs/ I can be seen "working" in Atlanta πŸ€“ and here https://www.instagram.com/p/B0BR06BgHBT/ in Dubrovnik πŸ˜ŽRecently, on the way to the FDA I traveled through WA DC's union station where the main hall is more impressive than ever with the holiday decorations https://www.instagram.com/p/B6L4--vFct8/ and like NYC Baltimore is also ballin' for Christmas https://www.instagram.com/p/B6WSrYEg4GL/

In Shanghai I met up with two former colleagues from the Institute for Systems Biology in Seattle, Biaoyang Lin of Zhejiang University and Wei Yan of Shanghai Jiao Tong University, both of whom have gone on to Professorships in China and are pictured here with me in front of the Parliament building:https://www.instagram.com/p/B2ZKXzcA3Mu/ Unlike me when they left Seattle, they left their families behind. Neither seemed happy about this, but you gotta go where the work is and their now Americanized families were not interested in moving back. For the record I tried this scam on Donna when we moved to Baltimore, but she would not go for it πŸ™„ Notably, as dual Chinese - American nationals they are no longer as Chinese as they use to be and can't work on certain classified projects there. BTW: the Chinese are killing it in Shanghai with architecture as witnessed in the beer bottle opener building next to Shanghai's famous tower https://www.instagram.com/p/B2ZKuNggEmQ/



I finally made it to Africa this year where in Accra, Ghana I spoke at the University of Ghana about our work in microbial diagnostics, sepsis and biomarkers. While I'm comfortable being a minority, Baltimore is 65% African (American Africans and African Africans - loads of which are Nigerian), in Ghana an Anglo really stands out πŸ‘€  Notably, at Ningbo University near Shanghai there were quite a few Africans on campus but in Accra, while there were many Chinese in the city, due to the Chinese push to gain influence, I didn't see any pale skin on campus. That was odd because campuses are usually hot zones of cultural mixing. Maybe this is just a sign that the University of Ghana is on the rise rather than having made it. In Accra the thing that stood out most was the style of dress for men and women. Lots of eye popping colors as seen in this photo at a textile outlet https://www.instagram.com/p/B4XYU2_A8dv/  

The other thing that stood out was the amazing hospitality of Ghanaians. It made me wonder if this is a relic of the British system Ghana and other British colonies experienced: an organized society with instilled manners of social behavior. Possibly, as most ex-British colonies seem to have no shortage of manners. Regardless, it is still a fairly poor country where the main hospital was built by the British over 100 years ago  https://www.instagram.com/p/B4RrUbFg62x/ and the street vendors perform amazing feats from their heads https://www.instagram.com/p/B4RlwdXA7sO/ Speaking of lovely architecture the Presidential residence - office known as Jubilee House is one of the most architecturally beautiful designs I have seen https://www.instagram.com/p/B4XYB5Eg0yO/ Ghana is a shining example of democracy in Africa with lots of room for growth in tourism and natural resources.

Meanwhile back in Baltimore David (Minter) Goodlett (aka the VII as in the 7th David Goodlett in a row but the first D. M. Goodlett) got through another year at the University of Maryland in their kinesiology program. He found some honest work this year for Jennifer Watson who runs several science conferences like www.asms.org, an annual event with 6-7k attendees. Jen's Mom, who started the company decades ago, fell in love with Mint and wanted to adopt him because of his manners and work ethic. Wait? What? Who knew? Looks like he'll get some more work with them in 2020. That's good as it's not clear he really knows what he wants to do when he graduates. Well, make a lot of money but he is not alone there. Judging from his choice of attire here https://www.instagram.com/p/B2ufB8eAlM3/  without loads of money to make it rain he may be pretty lonely πŸ˜œ 


Graham continued his convalescence away from school. Still no resolution to his chronic muscle pain that saw him drop out of University of Maryland's engineering program January 2018. As of this year only one of the four of us has not been hospitalized since moving to Baltimore, i.e. Donna. Graham had his stint back in September a result of medication and diet that saw him in for a week rebalancing his blood chemistry πŸ₯Ί Earlier in the year we tried to get him into the NIH's undiagnosed disease network but their reply was "we don't think we can help you". Ah right, so they are running a network for recognizable diseases that have not been diagnosed. Probably just trying to take in patients they know they can help which helps their success rate and and funding from Congress. Pathetic. Change the name of your damn program, NIH! ... We are now close to getting him into Cedar Sinai's undiagnosed disease network. Stay tuned. Hopefully, by next year there will be some resolution. Regardless, he turned 22 this year https://www.instagram.com/p/B4H0DSHAOSv/ 


It's been mostly a great year with lots to be thankful for like this Bolton Hill mansion from which we can walk to work, grocery store, pharmacy, doctor, dentist, hardware store, movie theater, opera house, symphony, dinner-drinks, and train station. For Donna, proximity to the train station means she is only 45 minutes away from all the best protests in WA DC. Notably, the best (45th) President ever and everyone knows it (his words not mine πŸ™„) does not disappoint there https://www.instagram.com/p/B1ZyNAdgYPp/. Alas, it doesn't seem possible that we could ever live such a pragmatic urban lifestyle for the money a Professor makes any where else. Certainly the same row house in Boston or NYC would cost 4x more than this 4k sq ft mansion in the heart of the city. Donna, seen here https://www.instagram.com/p/BwhcyCQhyQm/ at our favorite local eatery, Noona's by the Mt Royal light rail station and a ten minute walk from our place, continued her part-time work at Sunlight Natural Health http://sunlightnaturalhealth.com/ for a naturopathic doctor who is among the many Doctors treating Graham.

We hope to have exciting news to share in the new year. πŸŽ‰No. Donna is not pregnant again and no we didn't win the lottery πŸ˜œ For now we wish you all a happy holiday season and blessed new year. 


πŸ’•πŸ₯° πŸ™πŸΌDave, Donna, Mint, Ham and Trixie



P.S. For those interested in my work see the following link https://proteomics-now.com/speakers/35-dave-goodlett/index.html which I found while searching for a tweet from the lab. Seems the web never forgets πŸ‘€ I recall making the video in Finland but don't think I ever saw this webpage with a link to an interview of me that was made for an online proteomics forum. 

Monday, December 24, 2018

Christmas 2018


For our 31st wedding anniversary we traveled to Italy and Croatia, two places we both adore. While there I spoke twice at the Croatian Biophysics Society Summer school held in Split, which is where the Roman Emperor built his retirement palace. It was originally more like a fortress of course (www.diocletianspalace.org) which the modern city grew up around and into. Now melded seamlessly, the two are difficult to distinguish. We stayed at Marmontova apartments (www.marmontsplit.com/) run by a lovely family that put us only five minutes walk from the promenade where we consumed lots of sea air, wine and coffee at the many outdoor cafes. 
 

Split's food fresh and prepared

From Split we flew to Rome and took the train to Florence where I spoke at a workshop at the International Mass Spectrometry Conference (www.imsc2018.it/). We had both only ever been in Florence for one day each but not together. As time at the conference permitted we explored from a base at hotel Brunelleschi (www.brunelleschihotelflorence.com/) in the old town very near the Duomo. We skipped the Duomo tour due to long lines but went through the museum next to it, which contains loads of stone carved frescos from the original Gothic faΓ§ade to the cathedral. Well worth the visit just to see how folk use to learn about what was in the bible. LOL ... For example, I learned that Noah was fond of wine and going commando (lower right panel below where the actual caption was "Drunk Noah" LOL ... and just above you can see that Eve really did come out of Adam's side).

Old and new art of Florence

From Florence we spent a day in Rome and then were off to Dubrovnik to visit with the Master Hotelier of the Sesame (www.bbsesameinn.com/en-gb/photos), Misko Ecergovic. He always hugs Donna straight away on exiting the taxi ignoring me while collecting her baggage. Because he is one of those people who instantly make you feel like family, most nights he took the time to buy us nightcaps at a local seaside cafΓ©. Previously, we would just sit at his place, the Sesame (www.sesame.hr), where is partner Marina is the head chef and have drinks. Now though he has leased it out to better enjoy his family, but with Marina in place as chef the food remains delicious. The "retired" and well-seasoned Misko has lots of stories and opinions about life. For example, he favors the Socratic form of education which is difficult to accommodate in the modern education system. Adding to Misko's world view is the time he and his son were interred in a “concentration” camp during part of the Croatian Independence War (1991-1995). The Sesame Inn and restaurant are both in a stone building long owned by the family with the rooms decorated by artwork from when the lower floors were an art gallery.

Dubrovnik scenes

No visit to Dubrovnik would be complete without a stay in Cavtat, which is the village closest to the airport. If you can afford it, Hotel Croatia is the place to stay (hotel-croatia.cavtat.hotels-hr.com/en/). An all-inclusive resort built during Yugoslav times it was briefly occupied by Montenegrin forces during the war. A short stroll around the bay takes you to one of our favorite restaurants, Bugenvila (bugenvila.eu/). The harbor water is so clean and clear that you could literally jump in for a swim after dinner or maybe just to float around. 


 Scenes from Lokrum

Scenes from Cavtat

Meanwhile in Baltimore, other things happened that kept us occupied in 2018. Some good. Some, not so good. In my case, I continued to search for a new home for the lab. Insert the politics of academics, which makes everything more complicated than it needs to be, and the best I can say is that we love living in Baltimore but my job - not so much. I can only say here that the power brokers of academic politics are often outside the reaches of the normal legal system leaving Professors to fend for themselves. Hopefully, the situation will resolve in 2019. On the bright side of 2018 at work, six students graduated from the lab with their Doctor of Philosophy degrees (aka PhD = piled higher and deeper). This was really a great bunch of students who either began in year one or two after our move here in 2013. When I first started in academics in 2004, Sam Miller - a colleague in Seattle who was a few years ahead of me - said that students keep you young. Absolutely true. In many ways they are like adopted children who grow into young adulthood while with you. It's a blessing to have so many of them to enrich my life.



Baltimore scenes

In January Graham, having been at College Park for only a week of his 4th semester, was back home unable to go on. After three semesters of success in math and physics and chemistry, he had just been admitted to the very competitive Chemical Engineering program at the University of Maryland. Going back to his start, the night before starting at College Park in Fall 2016 he received a Lyme disease diagnosis and started antibiotic therapy. However, by January 2018 his symptoms were worse to the point where he was dealing with so much pain that he had to drop out being unable to use his hands except like you might with no opposable thumb. For him, 2018 went by going through various therapies, but his symptoms did not resolve. We are now more convinced than before that his symptoms are not due to Lyme and have begun the process of going through various specialists to try to sort out this medical mystery.


 Mint and Ham

Mint (aka David Minter) continued the year at College Park without his brother and in their kinesiology program and will probably also end with a minor in business from his time at Towson University. We think he’ll finish Fall 2019 and then who knows. Medical school? Graduate school? Physical therapy school? Time to decide later because like his second grade math teacher explained to us during a conference “this kid will never die of a heart attack”. At least in public he never seems to lose his cool, which is an admirable trait. This though cannot be said of his watching Auburn University football games. Given the team’s woes this year, the curses flew fast and furious at the TV. So animated were he and I during games that Trixie usually left the room after just a few minutes into the first quarter. War Eagle, damnit!!!!

In a story line that might be heard in a country song, the dog - Trixie - cost me at least $2000 when one of her toes was remove due to a malignancy. We were told this was cheaper than chemotherapy. Chemotherapy? For a dog? Yep. It's a thing. So, I thought to myself - self - this is thousands more than the standard American veterinary care in the back country that my Grandpa administered as needed. Not long after the toe was removed, she went in to have a tooth removed. Back home, she was missing five teeth! When I asked how much that cost, “you don't want to know” was the reply.   However, it had to be cheaper than the crown put on one of my molars recently. When I told Donna this would cost $340, she growled “why didn’t insurance pay@#$%!?” to which I replied “they paid half”. LOL. C'est la vie. I still don't know how much the dog’s dental work cost, but more than mine I bet@#$%^&*!

Donna continues to work at Sunlight Natural Health (sunlightnaturalhealth.com/) helping out in the office. She also spent the year as a patient of Arivale (www.arivale.com), a company founded by my former boss Leroy Hood (en.wikipedia.org/wiki/Leroy_Hood) at the Institute for Systems Biology (systemsbiology.org). Arivale use massive amounts of patient specific data they collect along with lifestyle surveys to reshape your biochemistry by reshaping your interactions with the world. This is certainly one version of the future of personalized medicine that I recommend keeping an eye on. As an aside, early in the year Donna received the results of her 23andme genomic analysis (www.23andme.com). As expected given our geographic genealogy for the last couple hundred years she was mostly Irish, English and Scot but there was a small % of Finnish of all things. No idea where this came from if not from some Finns involved in the Viking raids of the UK. I'm waiting on my kit but I'll be shocked if it is much different than hers save for perhaps the Finnish component.

You can find us on Facebook, Instagram (instagram.com/davegoodlett/) and twitter (twitter.com/goodlettlab1) and for now in Baltimore but who knows where we might be this time next year. We are only 20 minutes drive from BWI airport and 10 minutes walk to Penn station, which takes you to WA DC in 45 minutes or NYC in a couple hours. So, please stop by when you are in town.

Happy Holidays from the Baltimore Goodletts ...


 Runner up photos from 2018

You have got to be kidding...

Patio

Bugenvila G&T

Split

Split smiles

Piazza del Duomo

Arch d' Firenze

Ponte Vecchio

Trevi fountain smiles

Incheon

Bros @ Cinghiale DEC 2017

Bros Christmas Day 2017


Comfy

Not your chair, Dave

Twice in 2018

Ryan Burns' music shack in Burien, WA



HEL to ICN Finnair business class

HEL to GDN

Is that big chicken staying?

Bros @ Loch Bar for April - May b'day celebrations

Really?

FFS


 Bros @Cinghiale DEC 2018

OCT Steak cake for b'day 21

 Bros 26 OCT 2018

 Gilded


 Washington's impressive "monument"

Donna's stocking acting out.

 ...and they did

Thanks Erik Nilsson for a wee dram of Iceland

Faded Glory

Baltimore's Artscape 

 Donna at Neal and Joe's hair salon

 Ridiculous

 ICCVS gang at MSBM

 MSBM's 2018 class

 That's right DPAK. Swim trunks. Not underwear. LOL!

 Istria bitters

 Whew! I needed that ...



 Southern end DBV harbor

Watching world cup in DBV

 Being introduced to MSBM for lecture

on the way to DBV harbor

 DBV

That's all folks
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